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It works in most 5-mans and in heroic mode it might be quite useful, however it is not fair that starting with karazhan nearly everything is immune to this shot whilst all other silencing / interupting abilities still work.
I dissagree, I used it quite often in Karazhan.
Trashmobs: almost all casting mobs can be interupted with silencing shot.
Warlocks before the Shade of Aran
Sorcerous Shades (insane magic damage, must be interupted at all times else it is a wipe)
Mana feeders before the Curator
It also interupts the Shade of Aran's casting (except arcane missiles) so it must be used on cooldown there as well.
I use it for pulling casters in instances and heroics.
But tranq shot... I haven't found any mob except Aeonus afected by it, maybe it would be nice if it also affected Warlord Kalithresh's rage but it doesn't.
Basically it is a skill which was put in the game in an extremely insulting way by blizzard to ensure people would take at least one poor hunter in raids in the old times...
They couldn't make us desirable, they just made certain mobs unbeatable unless a hunter was there too...