There are no "best" professions. If there was everyone would have them.
To chooses which onesyou want you need to decide what you want from your professions.
If you want to make your own weapons then mining+blacksmithing is the way.
If you want to make your own rings, necklaces, trinkets and gems then mining+jewelcrafting is best.
If you want to make your own armour then skinning+leatherworking would be the choice.
However if you want to make money then skining+herbalism/mining is the route.
Remember you can also learn first aid, cooking and fishing with no impact on your 2 professions.
Edited, Feb 28th 2007 7:01am by magret