Hmm, where to start.
Crafting: In EQ2 you harvest your components, spend time at a machine making your items, and a lot of the results are actually worth something to other players in the game. In EQ1 you usually have to kill mobs in hopes of having certain components drops (so many types of mobs for some things), but the "crafting" part is easier (just click combine on the recipe in the tradeskill container and it makes it), however, a great majority crafted items are not desired at all.
Combat: This is probably one of the few things I still like in EQ1 over EQ2. EQ1 combat is usually longer but you can actually use a lot more strategy than EQ2. To me, EQ2 combat feels like a "roll your head across the keyboard and the fight is done in 20 seconds!". Maybe grouping/raiding is different, I grouped and raided a lot in EQ1 but mostly avoid it now.
Gaining Experience: Like Nadenu mentioned, game play is more tedious and leveling is slower in EQ1. The different is that EQ2 actually sincerely focused their game on questing, whereas EQ1 quests feel like an afterthought. For the most part, you spend hours upon hours grinding the same mobs over and over in EQ1 to get AA points and/or levels, and it honestly gets very old very fast. They have been adding more and more mission type quests to the game the past few expansions but there's still a vast gap between the two games there.
There's tons of other stuff to compare but I think that addresses what most people would be curious about offhand.