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I've been doing most of them while in a zone. Im that guy that has to do everything in one area before he moves on. I also have this compulsive need to gather everything I see, worthless or not.
That's my favorite way of doing them too.
As for not completing traits you're sure you'll never use; I'm doing ones I don't expect to equip because now I'm trying to tweak around my stats and this gives me more options. Well, I'm compulsive too.
Get them well underway by first getting the quests in an area. Keep getting new quests as they become available. You'll end up with a chunk of the required kills already well underway before you have to mob grind. Going back and grinding trait deeds on grey mobs isn't all that much fun.