well im just a noob at beastmastery myself, but, you only need one dna sample per creature, and at creation only. during each experimentation you need a single lyrase enzyme, which you can obtain by foraging, as a general rule only use the 8+ point ones, pref with a useful ability, the enzymes you get from creatures you need 2 of, but, the higher level the creature, the better quality the enzyme, so go kill some level 90 creatures for it. i've only managed to obtain the hydrolase enzymes by buying them, not sure how you obtain them otherwise - but the better purity etc the better obviously. the only other things of course, is the incubator quality, and the quality of the geothermal that you use. training up creatures is.... time consuming though, though i have to say, the creatures created do seem to be very tough, at level 1 my creature was killing level 8's no problem.. currently managed to get him to level 9, and he's taking on level 16's if this carries on throughout the levels, then creatures represent a very strong weapon. as a creature levels up, it also gains training points, unfortunatley, you have to learn the various creature abilities by observing other creatures in combat, still got lots left to learn about it myself, but its interesting so far.