I've mapped my shortcuts to ctrl/alt/shift + qwe, asd, zxc. This way I can have a maximum of 9*3 actions right at my fingertips. Warning though, it takes LOTS of practice to remember all those actions :) I've been playing with this configuration for two weeks now, and I still don't remember all the shortcuts. I do have cheatsheet under my monitor, which was very useful on the first week.
Here's how it goes:
CTRL+
Q = Charge
W = Hamstring
E = Heroic Strike
A = Thunder Clap
S = War Stomp
D = Intimidating Shout
Z = Blood Thirst
X = Rampage
C = Pummel
ALT+
Q = Intercept
W = Death Wish
E = Blood Rage
A = Blade Fist (trinket)
S =
D =
Z = Equip 1H + Shield
X = Equip 1H + 1H
SHIFT+
Q = Def stance
W = Battle Stance
E = Berserk Stance
A = Taunt
S = Mocking Blow
D = Challenging Shout
Z = Revenge
X = Sunder Armor
C = Shield Block
There's just one problem with this : moving while using a skill is difficult. Especially "strafe-turning", so you can't PvP with this setup. I use wasd + mouse for moving, constantly switching from w to both mouse buttons, depending on what I need at the moment ( W while I'm selecting a target, then I switch to mouse-run to hit the skill. But if I'm slow to use the skills, I'll easily run past the mob :)