out of the two i'd say family guy. there is raw humor as well as those little subtle clues that the person behind it is not only funny but highly intelligent as well.
simpsons is good but just old.
ATHF is funny, but like that other one (with the super hero dude doing the talk show...help me out) is REALLY twisted. if I had to vote on twisted though I would definately say sealab...that show cracks me up...like they intentionally try to push the line as far as they can then jump over it.